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The 2′-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC
The ribosome accelerates the rate of peptidyl transfer by >10(6)-fold relative to the background rate. A widely accepted model for this rate enhancement invokes entropic effects whereby the ribosome and the 2′-OH of the peptidyl-tRNA substrate precisely position the reactive moieties through an e...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3116277/ https://ncbi.nlm.nih.gov/pubmed/21552203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.142 |
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