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Peptide release on the ribosome depends critically on the 2′ OH of the peptidyl–tRNA substrate
Peptide release on the ribosome is catalyzed by protein release factors (RFs) on recognition of stop codons positioned in the A site of the small ribosomal subunit. Here we show that the 2′ OH of the peptidyl–tRNA substrate plays an essential role in catalysis of the peptide release reaction. These...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2491474/ https://ncbi.nlm.nih.gov/pubmed/18567817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1057908 |
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