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Templated synthesis of nylon nucleic acids and characterization by nuclease digestion

Nylon nucleic acids containing oligouridine nucleotides with pendent polyamide linkers and flanked by unmodified heteronucleotide sequences were prepared by DNA templated synthesis. Templation was more efficient than the single-stranded synthesis: Coupling step yields were as high as 99.2%, with up...

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Main Authors: Liu, Yu, Wang, Risheng, Ding, Liang, Sha, Roujie, Seeman, Nadrian C., Canary, James W.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486707/
https://ncbi.nlm.nih.gov/pubmed/23125913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2SC20129A
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