DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: modulation by ionic strength and superhelicity.

Superhelical and partially relaxed DNAs of simian virus 40 were allowed to react in vitro with (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP diol epoxide). The modified DNA contained N2 guanine and N6 adenine hydrocarbon adducts in the ratio 86:14. Supe...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Gamper, H B, Straub, K, Calvin, M, Bartholomew, J C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1980
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348638/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6246517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.4.2000
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