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Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids.

The alkylation of DNA by racemic 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) exhibits a strong preference for formation of trans adducts between the N2 deoxyguanosine alkylation site and the (+)-enantiomer of anti-BPDE. In the presence of 10 mM buffer with no added sal...

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Bibliografische gegevens
Hoofdauteurs: Wolfe, A R, Yamamoto, J, Meehan, T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1994
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC43160/
https://ncbi.nlm.nih.gov/pubmed/8108418
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