DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: modulation by ionic strength and superhelicity.

Superhelical and partially relaxed DNAs of simian virus 40 were allowed to react in vitro with (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP diol epoxide). The modified DNA contained N2 guanine and N6 adenine hydrocarbon adducts in the ratio 86:14. Supe...

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Bibliographic Details
Main Authors: Gamper, H B, Straub, K, Calvin, M, Bartholomew, J C
Format: Artigo
Language:Inglês
Published: 1980
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC348638/
https://ncbi.nlm.nih.gov/pubmed/6246517
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