The Loss of RGS Protein-Gα(i2) Interactions Results in Markedly Impaired Mouse Neutrophil Trafficking to Inflammatory Sites

Neutrophils are first responders rapidly mobilized to inflammatory sites by a tightly regulated, nonredundant hierarchy of chemoattractants. These chemoattractants engage neutrophil cell surface receptors triggering heterotrimeric G-protein Gα(i) subunits to exchange GDP for GTP. By limiting the dur...

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Main Authors: Cho, Hyeseon, Kamenyeva, Olena, Yung, Sunny, Gao, Ji-Liang, Hwang, Il-Young, Park, Chung, Murphy, Philip M., Neubig, Richard R., Kehrl, John H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486189/
https://ncbi.nlm.nih.gov/pubmed/22966200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00651-12
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