Subtilase Cytotoxin Enhances Escherichia coli Survival in Macrophages by Suppression of Nitric Oxide Production through the Inhibition of NF-κB Activation

Subtilase cytotoxin (SubAB), which is produced by certain strains of Shiga-toxigenic Escherichia coli (STEC), cleaves an endoplasmic reticulum (ER) chaperone, BiP/Grp78, leading to induction of ER stress and caspase-dependent apoptosis. SubAB alters the innate immune response. SubAB pretreatment of...

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Bibliographische Detailangaben
Hauptverfasser: Tsutsuki, Hiroyasu, Yahiro, Kinnosuke, Suzuki, Kotaro, Suto, Akira, Ogura, Kohei, Nagasawa, Sayaka, Ihara, Hideshi, Shimizu, Takeshi, Nakajima, Hiroshi, Moss, Joel, Noda, Masatoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486033/
https://ncbi.nlm.nih.gov/pubmed/22949549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00581-12
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