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Regulation of Subtilase Cytotoxin-Induced Cell Death by an RNA-Dependent Protein Kinase-Like Endoplasmic Reticulum Kinase-Dependent Proteasome Pathway in HeLa Cells

Shiga-toxigenic Escherichia coli (STEC) produces subtilase cytotoxin (SubAB), which cleaves the molecular chaperone BiP in the endoplasmic reticulum (ER), leading to an ER stress response and then activation of apoptotic signaling pathways. Here, we show that an early event in SubAB-induced apoptosi...

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Bibliografski detalji
Glavni autori: Yahiro, Kinnosuke, Tsutsuki, Hiroyasu, Ogura, Kohei, Nagasawa, Sayaka, Moss, Joel, Noda, Masatoshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347452/
https://ncbi.nlm.nih.gov/pubmed/22354021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06164-11
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