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Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1α or JNK signaling

Subtilase cytotoxin (SubAB) is an AB(5) cytotoxin produced by some strains of Shiga-toxigenic Escherichia coli. The A subunit is a subtilase-like serine protease and cleaves an endoplasmic reticulum (ER) chaperone, BiP, leading to transient inhibition of protein synthesis and cell cycle arrest at G(...

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Библиографические подробности
Главные авторы: Yahiro, Kinnosuke, Morinaga, Naoko, Moss, Joel, Noda, Masatoshi
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417112/
https://ncbi.nlm.nih.gov/pubmed/20561923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.micpath.2010.05.007
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