Novel Subtilase Cytotoxin Produced by Shiga-Toxigenic Escherichia coli Induces Apoptosis in Vero Cells via Mitochondrial Membrane Damage

Subtilase cytotoxin (SubAB) is an AB(5) cytotoxin produced by some strains of Shiga-toxigenic Escherichia coli. The A subunit is a subtilase-like serine protease and cleaves an endoplasmic reticulum chaperone, BiP, leading to transient inhibition of protein synthesis and cell cycle arrest at G(1) ph...

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Main Authors: Matsuura, Gen, Morinaga, Naoko, Yahiro, Kinnosuke, Komine, Reiko, Moss, Joel, Yoshida, Hideo, Noda, Masatoshi
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
主題:
Bacterial Infections
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708566/
https://ncbi.nlm.nih.gov/pubmed/19380466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01510-08
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