Phase I Safety and Immunogenicity Evaluations of an Alphavirus Replicon HIV-1 Subtype C gag Vaccine in Healthy HIV-1-Uninfected Adults

On the basis of positive preclinical data, we evaluated the safety and immunogenicity of an alphavirus replicon HIV-1 subtype C gag vaccine (AVX101), expressing a nonmyristoylated form of Gag, in two double-blind, randomized, placebo-controlled clinical trials in healthy HIV-1-uninfected adults. Esc...

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Main Authors: Wecker, M., Gilbert, P., Russell, N., Hural, J., Allen, M., Pensiero, M., Chulay, J., Chiu, Ya-Lin, Abdool Karim, S. S., Burke, D. S.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
主題:
Vaccines
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485893/
https://ncbi.nlm.nih.gov/pubmed/22914365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00258-12
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