PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

PPARβ/δ protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined. To gain insight into its hypothesized role in β cell function, we specifically deleted Pparb/d in the epithelial c...

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Hlavní autoři: Iglesias, José, Barg, Sebastian, Vallois, David, Lahiri, Shawon, Roger, Catherine, Yessoufou, Akadiri, Pradevand, Sylvain, McDonald, Angela, Bonal, Claire, Reimann, Frank, Gribble, Fiona, Debril, Marie-Bernard, Metzger, Daniel, Chambon, Pierre, Herrera, Pedro, Rutter, Guy A., Prentki, Marc, Thorens, Bernard, Wahli, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484427/
https://ncbi.nlm.nih.gov/pubmed/23093780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42127
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