BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation

We previously reported the development of a lethal myeloid sarcoma in a non-human primate model utilizing retroviral vectors to genetically modify hematopoietic stem and progenitor cells. This leukemia was characterized by insertion of the vector provirus into the BCL2A1 gene, with resultant BCL2A1...

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Main Authors: Métais, Jean-Yves, Winkler, Thomas, Geyer, Julia T., Calado, Rodrigo T., Aplan, Peter D., Eckhaus, Michael A., Dunbar, Cynthia E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484072/
https://ncbi.nlm.nih.gov/pubmed/23118966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048267
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