BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation

We previously reported the development of a lethal myeloid sarcoma in a non-human primate model utilizing retroviral vectors to genetically modify hematopoietic stem and progenitor cells. This leukemia was characterized by insertion of the vector provirus into the BCL2A1 gene, with resultant BCL2A1...

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Autors principals: Métais, Jean-Yves, Winkler, Thomas, Geyer, Julia T., Calado, Rodrigo T., Aplan, Peter D., Eckhaus, Michael A., Dunbar, Cynthia E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484072/
https://ncbi.nlm.nih.gov/pubmed/23118966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048267
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