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Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

Genome-wide association studies (GWASs) have identified thousands of single nucleotide polymorphisms (SNPs) associated with human traits and diseases. But because the vast majority of these SNPs are located in the noncoding regions of the genome their risk promoting mechanisms are elusive. Employing...

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Détails bibliographiques
Auteurs principaux: Cowper-Sal·lari, Richard, Zhang, Xiaoyang, Wright, Jason B., Bailey, Swneke D., Cole, Michael D., Eeckhoute, Jerome, Moore, Jason H., Lupien, Mathieu
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483423/
https://ncbi.nlm.nih.gov/pubmed/23001124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2416
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