UPR-Induced Resistance to Etoposide Is Downstream of PERK and Independent of Changes in Topoisomerase IIα Levels

BACKGROUND: The unfolded protein response (UPR) is regulated by three ER-localized, transmembrane signal transducers that control distinct aspects of the UPR. We previously reported that both increased resistance to etoposide and a reduction in Topoisomerase IIα protein levels were a direct response...

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Main Authors: Mann, Melissa J., Pereira, Ethel R., Liao, Nan, Hendershot, Linda M.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483293/
https://ncbi.nlm.nih.gov/pubmed/23144714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047931
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