Sialylation Determines the Nephritogenicity of IgG3 Cryoglobulins

Monoclonal 6-19 IgG3 anti-IgG2a rheumatoid factor derived from lupus-prone MRL-Fas(lpr) mice can induce GN and cryoglobulinemia, but the features that confer nephritogenic potential are not completely understood. Asparagine-linked oligosaccharide chains of 6-19 IgG3 mAb are poorly galactosylated and...

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Autors principals: Otani, Masako, Kuroki, Aki, Kikuchi, Shuichi, Kihara, Masao, Nakata, Junichiro, Ito, Kiyoaki, Furukawa, Jun-ichi, Shinohara, Yasuro, Izui, Shozo
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2012
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482736/
https://ncbi.nlm.nih.gov/pubmed/23024299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050477
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