O-Linked Glycosylation Determines the Nephritogenic Potential of IgA Rheumatoid Factor

Deficient glycosylation of O-linked glycans in the IgA1 hinge region is associated with IgA nephropathy in humans, but the pathogenic contribution of the underlying structural aberrations remains incompletely understood. We previously showed that mice implanted with cells secreting the class-switch...

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Bibliographic Details
Main Authors: Kihara, Masao, Ito, Kiyoaki, Nakata, Junichiro, Otani, Masako, Tran, Ngoc Lan, Morito, Naoki, Takahashi, Satoru, Wada, Yoshinao, Izui, Shozo
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2014
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033374/
https://ncbi.nlm.nih.gov/pubmed/24511137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070771
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