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O-Glycosylated IgA Rheumatoid Factor Induces IgA Deposits and Glomerulonephritis

Structural aberrations of O-linked glycans present in the IgA1 hinge region are associated with IgA nephropathy, but their contribution to its pathogenesis remains incompletely understood. In this study, mice implanted with hybridoma secreting 6-19 IgA anti-IgG2a rheumatoid factor, but not 46-42 IgA...

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Hlavní autoři: Otani, Masako, Nakata, Junichiro, Kihara, Masao, Leroy, Valérie, Moll, Solange, Wada, Yoshinao, Izui, Shozo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294307/
https://ncbi.nlm.nih.gov/pubmed/22193386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011070701
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