PGD(2)-CRTH2 Pathway Promotes Tubulointerstitial Fibrosis

Urinary excretion of lipocalin-type PGD(2) synthase (L-PGDS), which converts PG H(2) to PGD(2), increases in early diabetic nephropathy. In addition, L-PGDS expression in the tubular epithelium increases in adriamycin-induced nephropathy, suggesting that locally produced L-PGDS may promote the devel...

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Détails bibliographiques
Auteurs principaux: Ito, Hideyuki, Yan, Xiaoxiang, Nagata, Nanae, Aritake, Kosuke, Katsumata, Yoshinori, Matsuhashi, Tomohiro, Nakamura, Masataka, Hirai, Hiroyuki, Urade, Yoshihiro, Asano, Koichiro, Kubo, Masato, Utsunomiya, Yasunori, Hosoya, Tatsuo, Fukuda, Keiichi, Sano, Motoaki
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2012
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482731/
https://ncbi.nlm.nih.gov/pubmed/22997255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012020126
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