Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D(2)

Prostaglandin D(2) (PGD(2)) is a lipid mediator involved in sleep regulation and inflammation. PGD(2) interacts with 2 types of G protein-coupled receptors, DP1 and DP2/CRTH2 (chemoattractant receptor homologous molecule expressed on T helper type 2 cells)/GPR44 to show a variety of biological effec...

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Veröffentlicht in:PLoS One
Hauptverfasser: Nagata, Nanae, Iwanari, Hiroko, Kumagai, Hidetoshi, Kusano-Arai, Osamu, Ikeda, Yuichi, Aritake, Kosuke, Hamakubo, Takao, Urade, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386288/
https://ncbi.nlm.nih.gov/pubmed/28394950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175452
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