Activation of Liver X Receptor Inhibits Osteopontin and Ameliorates Diabetic Nephropathy

Osteopontin is a proinflammatory cytokine and monocyte chemoattractant implicated in the pathogenesis of diabetic nephropathy. Synthetic agonists for liver X receptors (LXRs) suppress the expression of proinflammatory genes, including osteopontin, but whether LXR activation modulates diabetic nephro...

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Autori principali: Tachibana, Hiromi, Ogawa, Daisuke, Matsushita, Yuichi, Bruemmer, Dennis, Wada, Jun, Teshigawara, Sanae, Eguchi, Jun, Sato-Horiguchi, Chikage, Uchida, Haruhito Adam, Shikata, Kenichi, Makino, Hirofumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2012
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482729/
https://ncbi.nlm.nih.gov/pubmed/23085633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012010022
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