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Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone and their combination as endogenous probes for inhibition of CYP3A4 in vivo
An endogenous probe for CYP3A activity would be useful for early identification of in vivo CYP3A4 inhibitors. The aim of this study was to determine whether formation clearance (CL(f)) of the sum of 6β-hydroxycortisol and 6β-hydroxycortisone is a useful probe of CYP3A4 inhibition in vivo. In human l...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3481835/ https://ncbi.nlm.nih.gov/pubmed/21490593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.53 |
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