Poor correlation between 6β-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity

AIMS: A non-invasive proposed method for measuring CYP3A activity is the urinary 6β-hydroxycortisol:cortisol ratio. This ratio has been used as an indicator of CYP3A induction and inhibition, with mixed results. This investigation evaluated the relationship between a validated, biomarker, intravenou...

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Detalhes bibliográficos
Main Authors: Chen, Ya-Chi, Gotzkowsky, S Karl, Nafziger, Anne N, Kulawy, Robert W, Rocci, Mario L, Bertino, Joseph S, Kashuba, Angela D M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885097/
https://ncbi.nlm.nih.gov/pubmed/16842393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02628.x
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