Crystal Structures of the Scaffolding Protein LGN Reveal the General Mechanism by Which GoLoco Binding Motifs Inhibit the Release of GDP from Gα(i)

GoLoco (GL) motif-containing proteins regulate G protein signaling by binding to Gα subunit and acting as guanine nucleotide dissociation inhibitors. GLs of LGN are also known to bind the GDP form of Gα(i/o) during asymmetric cell division. Here, we show that the C-terminal GL domain of LGN binds fo...

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Autors principals: Jia, Min, Li, Jianchao, Zhu, Jinwei, Wen, Wenyu, Zhang, Mingjie, Wang, Wenning
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481280/
https://ncbi.nlm.nih.gov/pubmed/22952234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391607
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