The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL

Besides inducing apoptosis, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates NF-κB. The apoptosis signaling pathway of TRAIL is well characterized involving TRAIL receptors, Fas-associated protein with death domain (FADD) and caspase-8. In contrast, the molecular mechanism o...

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Autors principals: Grunert, M, Gottschalk, K, Kapahnke, J, Gündisch, S, Kieser, A, Jeremias, I
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481141/
https://ncbi.nlm.nih.gov/pubmed/23096115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.154
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