Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity

BACKGROUND AND PURPOSE: Amyloid-β (Aβ) aggregation into synaptotoxic, prefibrillar oligomers is a major pathogenic event underlying the neuropathology of Alzheimer's disease (AD). The pharmacological and neuroprotective properties of a novel Aβ aggregation inhibitor, SEN1269, were investigated...

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Autors principals: Scopes, DIC, O'Hare, E, Jeggo, R, Whyment, AD, Spanswick, D, Kim, E-M, Gannon, J, Amijee, H, Treherne, JM
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481045/
https://ncbi.nlm.nih.gov/pubmed/22913627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01973.x
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