Tau oligomers impair memory and synaptic plasticity through the cellular prion protein

Abstract Deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in Alzheimer’s disease (AD) and other tauopathies. Among tau aggregates, oligomers (TauOs) are considered the most toxic. AD brains show significant increase in TauOs compared...

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Bibliografske podrobnosti

Principais autores:	Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-01-01
Serija:	Acta Neuropathologica Communications
Teme:	Tau oligomers Prion protein Memory impairment Synaptic dysfunction Alzheimer’s disease
Online dostop:	https://doi.org/10.1186/s40478-025-01930-3
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