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Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity
In Alzheimer’s disease (AD), insoluble and fibrillary amyloid-β (Aβ) peptide accumulates in plaques. However, soluble Aβ oligomers are most potent in creating synaptic dysfunction and loss. Therefore, receptors for Aβ oligomers are hypothesized to be the first step in a neuronal cascade leading to d...
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| 出版年: | Cold Spring Harb Perspect Med |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5411685/ https://ncbi.nlm.nih.gov/pubmed/27940601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024075 |
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