Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant

BACKGROUND & AIMS: Adult stem cells have been proposed to be quiescent and radiation resistant, repairing DNA double-strand breaks by nonhomologous end joining. However, the population of putative small intestinal stem cells (ISCs) at position +4 from the crypt base contradicts this model, in th...

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Main Authors: HUA, GUOQIANG, THIN, TIN HTWE, FELDMAN, REGINA, HAIMOVITZ-FRIEDMAN, ADRIANA, CLEVERS, HANS, FUKS, ZVI, KOLESNICK, RICHARD
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480544/
https://ncbi.nlm.nih.gov/pubmed/22841781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.07.106
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