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Impact of Stromal Sensitivity on Radiation Response of Tumors Implanted in SCID Hosts Revisited

Severe combined immunodeficient (SCID) mice carry a germ-line mutation in DNA-PK, associated with deficiency in recognition and repair DNA double strand breaks. Thus, SCID cells and tissues display increased sensitivity to radiation-induced post-mitotic (clonogenic) cell death. Nonetheless, the sing...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: García-Barros, Mónica, Thin, Tin Htwe, Maj, Jerzy, Cordon-Cardo, Carlos, Haimovitz-Friedman, Adriana, Fuks, Zvi, Kolesnick, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976483/
https://ncbi.nlm.nih.gov/pubmed/20924105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1871
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