Deubiquitinase USP9x Confers Radioresistance through Stabilization of Mcl-1

Myeloid cell leukemia sequence 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family, is often overexpressed in tumor cells limiting the therapeutic success. Mcl-1 differs from other Bcl-2 members by its high turnover rate. Its expression level is tightly regulated by ubiquitylating and deubiquityl...

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Detaylı Bibliyografya
Asıl Yazarlar: Trivigno, Donatella, Essmann, Frank, Huber, Stephan M, Rudner, Justine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press Inc. 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479835/
https://ncbi.nlm.nih.gov/pubmed/23097624
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