Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

Protein disulfide isomerase (PDI), an endoplasmic reticulum chaperone protein, catalyzes disulfide bond breakage, formation, and rearrangement. The effect of PDI inhibition on ovarian cancer progression is not yet clear, and there is a need for potent, selective, and safe small-molecule inhibitors o...

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Detaylı Bibliyografya
Asıl Yazarlar: Xu, Shili, Butkevich, Alexey N., Yamada, Roppei, Zhou, Yu, Debnath, Bikash, Duncan, Roger, Zandi, Ebrahim, Petasis, Nicos A., Neamati, Nouri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479552/
https://ncbi.nlm.nih.gov/pubmed/22988091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205226109
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