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Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5′ processing

Ribonuclease P (RNase P) catalyzes the maturation of the 5′ end of tRNA precursors. Typically these enzymes are ribonucleoproteins with a conserved RNA component responsible for catalysis. However, protein-only RNase P (PRORP) enzymes process precursor tRNAs in human mitochondria and in all tRNA-usi...

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Bibliografiske detaljer
Main Authors: Howard, Michael J., Lim, Wan Hsin, Fierke, Carol A., Koutmos, Markos
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479547/
https://ncbi.nlm.nih.gov/pubmed/22991464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209062109
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