Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P

Mitochondrial diseases linked to mutations in mitochondrial (mt) tRNA sequences are common. However, the contributions of these tRNA mutations to the development of diseases is mostly unknown. Mutations may affect interactions with (mt)tRNA maturation enzymes or protein synthesis machinery leading t...

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Bibliographic Details
Published in:RNA
Main Authors: Karasik, Agnes, Wilhelm, Catherine A., Fierke, Carol A., Koutmos, Markos
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962481/
https://ncbi.nlm.nih.gov/pubmed/33380464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.077198.120
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