Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

The type II p21-activated kinases (PAKs) are key effectors of RHO-family GTPases involved in cell motility, survival, and proliferation. Using a structure-guided approach, we discovered that type II PAKs are regulated by an N-terminal autoinhibitory pseudosubstrate motif centered on a critical proli...

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Autors principals: Ha, Byung Hak, Davis, Matthew J., Chen, Catherine, Lou, Hua Jane, Gao, Jia, Zhang, Rong, Krauthammer, Michael, Halaban, Ruth, Schlessinger, Joseph, Turk, Benjamin E., Boggon, Titus J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479536/
https://ncbi.nlm.nih.gov/pubmed/22988085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214447109
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