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Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling
Enpp1 is a membrane-bound glycoprotein that regulates bone mineralization by hydrolyzing extracellular nucleotide triphosphates to produce pyrophosphate. Enpp1 dysfunction causes human diseases characterized by ectopic calcification. Enpp1 also inhibits insulin signaling, and an Enpp1 polymorphism i...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479499/ https://ncbi.nlm.nih.gov/pubmed/23027977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208017109 |
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