Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

Enpp1 is a membrane-bound glycoprotein that regulates bone mineralization by hydrolyzing extracellular nucleotide triphosphates to produce pyrophosphate. Enpp1 dysfunction causes human diseases characterized by ectopic calcification. Enpp1 also inhibits insulin signaling, and an Enpp1 polymorphism i...

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Detaylı Bibliyografya
Asıl Yazarlar: Kato, Kazuki, Nishimasu, Hiroshi, Okudaira, Shinichi, Mihara, Emiko, Ishitani, Ryuichiro, Takagi, Junichi, Aoki, Junken, Nureki, Osamu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479499/
https://ncbi.nlm.nih.gov/pubmed/23027977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208017109
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