Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription

The molecular mechanisms linking glucose metabolism with active transcription remain undercharacterized in mammalian cells. Using nuclear factor-κB (NF-κB) as a glucose-responsive transcription factor, we show that cells use the hexosamine biosynthesis pathway and O-linked β-N-acetylglucosamine (O-G...

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Autori principali: Allison, David F., Wamsley, J. Jacob, Kumar, Manish, Li, Duo, Gray, Lisa G., Hart, Gerald W., Jones, David R., Mayo, Marty W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479489/
https://ncbi.nlm.nih.gov/pubmed/23027940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208468109
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