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Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription
The molecular mechanisms linking glucose metabolism with active transcription remain undercharacterized in mammalian cells. Using nuclear factor-κB (NF-κB) as a glucose-responsive transcription factor, we show that cells use the hexosamine biosynthesis pathway and O-linked β-N-acetylglucosamine (O-G...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479489/ https://ncbi.nlm.nih.gov/pubmed/23027940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208468109 |
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