Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs

The activating transcription factor 4 (ATF4) promotes transcriptional upregulation of specific target genes in response to cellular stress. ATF4 expression is regulated at the translational level by two short open reading frames (uORFs) in its 5′-untranslated region (5′-UTR). Here, we describe a mec...

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Autori principali: Ait Ghezala, Hayet, Jolles, Béatrice, Salhi, Samia, Castrillo, Katia, Carpentier, Wassila, Cagnard, Nicolas, Bruhat, Alain, Fafournoux, Pierre, Jean-Jean, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Gene Regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479206/
https://ncbi.nlm.nih.gov/pubmed/22904092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks762
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