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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene expression designed to ameliorate the underlying cellular disturbance. Central to this stress response is the transcriptional regulator activating transcription factor, ATF4. Here we describe the mechanis...

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Detalhes bibliográficos
Main Authors: Vattem, Krishna M., Wek, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509193/
https://ncbi.nlm.nih.gov/pubmed/15277680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400541101
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