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Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs
The activating transcription factor 4 (ATF4) promotes transcriptional upregulation of specific target genes in response to cellular stress. ATF4 expression is regulated at the translational level by two short open reading frames (uORFs) in its 5′-untranslated region (5′-UTR). Here, we describe a mec...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479206/ https://ncbi.nlm.nih.gov/pubmed/22904092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks762 |
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