Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway

In eukaryotes, multiple genes encode histone proteins that package genomic deoxyribonucleic acid (DNA) and regulate its accessibility. Because of their positive charge, ‘free’ (non-chromatin associated) histones can bind non-specifically to the negatively charged DNA and affect its metabolism, inclu...

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Main Authors: Liang, Dun, Burkhart, Sarah Lyn, Singh, Rakesh Kumar, Kabbaj, Marie-Helene Miquel, Gunjan, Akash
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479188/
https://ncbi.nlm.nih.gov/pubmed/22850743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks722
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