Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway

In eukaryotes, multiple genes encode histone proteins that package genomic deoxyribonucleic acid (DNA) and regulate its accessibility. Because of their positive charge, ‘free’ (non-chromatin associated) histones can bind non-specifically to the negatively charged DNA and affect its metabolism, inclu...

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Dettagli Bibliografici
Autori principali: Liang, Dun, Burkhart, Sarah Lyn, Singh, Rakesh Kumar, Kabbaj, Marie-Helene Miquel, Gunjan, Akash
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479188/
https://ncbi.nlm.nih.gov/pubmed/22850743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks722
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