Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway

In eukaryotes, multiple genes encode histone proteins that package genomic deoxyribonucleic acid (DNA) and regulate its accessibility. Because of their positive charge, ‘free’ (non-chromatin associated) histones can bind non-specifically to the negatively charged DNA and affect its metabolism, inclu...

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Main Authors: Liang, Dun, Burkhart, Sarah Lyn, Singh, Rakesh Kumar, Kabbaj, Marie-Helene Miquel, Gunjan, Akash
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479188/
https://ncbi.nlm.nih.gov/pubmed/22850743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks722
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