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Excess histone levels mediate cytotoxicity via multiple mechanisms

The accumulation of excess histone proteins in cells has deleterious consequences such as genomic instability in the form of excessive chromosome loss, enhanced sensitivity to DNA damaging agents and cytotoxicity. Hence, the synthesis of histone proteins is tightly regulated at multiple steps and tr...

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Detalhes bibliográficos
Main Authors: Singh, Rakesh Kumar, Liang, Dun, Gajjalaiahvari, Ugander Reddy, Kabbaj, Marie-Helene Miquel, Paik, Johanna, Gunjan, Akash
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055206/
https://ncbi.nlm.nih.gov/pubmed/20948314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.20.13636
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