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Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

The AcrAB–TolC multidrug efflux pump confers resistance to a wide variety of antibiotics and other compounds in Escherichia coli. Here we show that AcrZ (formerly named YbhT), a 49-amino-acid inner membrane protein, associates with the AcrAB-TolC complex. Co-purification of AcrZ with AcrB, in the ab...

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Main Authors: Hobbs, Errett C., Yin, Xuefeng, Paul, Brian J., Astarita, Jillian L., Storz, Gisela
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478662/
https://ncbi.nlm.nih.gov/pubmed/23010927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210093109
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