Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

Nicastrin (NCT) is a crucial component of the γ-secretase (GS) enzyme, which prompted investigations into its biological role in cancer. We have previously shown that nicastrin is overexpressed in breast cancer (BC), conferring worse overall survival in invasive, ERα negative patients. Here, we used...

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Détails bibliographiques
Auteurs principaux: Lombardo, Ylenia, Filipović, Aleksandra, Molyneux, Gemma, Periyasamy, Manikandan, Giamas, Georgios, Hu, Yunhui, Trivedi, Pritesh S., Wang, Jayson, Yagüe, Ernesto, Michel, Loren, Coombes, R. Charles
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478621/
https://ncbi.nlm.nih.gov/pubmed/23012411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206268109
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