Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

Nicastrin (NCT) is a crucial component of the γ-secretase (GS) enzyme, which prompted investigations into its biological role in cancer. We have previously shown that nicastrin is overexpressed in breast cancer (BC), conferring worse overall survival in invasive, ERα negative patients. Here, we used...

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Bibliografski detalji
Glavni autori: Lombardo, Ylenia, Filipović, Aleksandra, Molyneux, Gemma, Periyasamy, Manikandan, Giamas, Georgios, Hu, Yunhui, Trivedi, Pritesh S., Wang, Jayson, Yagüe, Ernesto, Michel, Loren, Coombes, R. Charles
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478621/
https://ncbi.nlm.nih.gov/pubmed/23012411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206268109
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