Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

Nicastrin (NCT) is a crucial component of the γ-secretase (GS) enzyme, which prompted investigations into its biological role in cancer. We have previously shown that nicastrin is overexpressed in breast cancer (BC), conferring worse overall survival in invasive, ERα negative patients. Here, we used...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lombardo, Ylenia, Filipović, Aleksandra, Molyneux, Gemma, Periyasamy, Manikandan, Giamas, Georgios, Hu, Yunhui, Trivedi, Pritesh S., Wang, Jayson, Yagüe, Ernesto, Michel, Loren, Coombes, R. Charles
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2012
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478621/
https://ncbi.nlm.nih.gov/pubmed/23012411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206268109
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